- Professor of Epidemiology, Department of Biostatistics and Epidemiology
- Associate Director for Population Science, Abramson Cancer Center
- Director, Laboratory for Molecular Epidemiology
- Director, Human Genetics Training Track, Epidemiology Graduate Group
- Senior Scholar, Center for Clinical Epidemiology and Biostatistics
- Fellow, Institute on Aging, University of Pennsylvania
Dr. Rebbeck received a B.A. in biology from Northwestern University in 1984, an Sc.M. in chronic disease epidemiology from the Johns Hopkins University School of Hygiene and Public Health in 1986, and an A.M. in statistics and Ph.D. in Human Genetics from the University of Michigan in 1991. His graduate work involved biometrical genetics methods applied to the study of essential hypertension. He subsequently undertook postdoctoral training in the molecular and genetic epidemiology of cancer and birth defects at the Fox Chase Cancer Center. Dr. Rebbeck joined the University of Pennsylvania in 1995. The goal of Dr. Rebbeck’s research is to identify genes associated with the etiology of breast, prostate, endometrial, and skin cancers; evaluate interactions of these genes with each other and with endogenous or exogenous exposures; and to translate this information to studies of cancer prevention and outcome.
Dr. Rebbeck leads molecular epidemiologic studies to identify and characterize cancer genes; to understand the relationship of allelic variation of these genes with cancer occurrence and cancer outcomes; and to evaluate the role of these genes in cancer etiology and outcomes in the context of the demographic, biochemical, environmental, and physiological risk factors. He has focused this research to address the following questions: 1) Why do men of African descent have higher incidence and poorer prognosis for prostate cancer compared to other groups? 2) How do we refine our understanding of cancer risk and prevention in women who have inherited BRCA1 or BRCA2 mutations? 3) How do genes, environments, and other contextual factors interact in the
etiology of commonly occurring cancers?